The prediction of vocational success following brain injury has recently received considerable attention in the literature. The majority of the studies have focused on work re-entry of individuals who were employed at the time of the injury. However, thirty-five to fifty percent of persons sustaining brain injury were not employed at the time of the injury. Given the relatively young age of the population, many of these individuals would have been preparing to enter the workforce at the time of the injury. Others may not have been working due to other reasons. The purpose of the current study is to determine how factors commonly associated with successful return to work interact with premorbid occupational status in the prediction of employment at one, two, and three years after discharge from rehabilitation in cross-sectional samples. An examination of whether these factors have a differential influence on the prediction of employment based on premorbid occupational status (employed vs. unemployed) can assist in determining how to increase the likelihood that a previously unemployed individual will enter the workforce post-injury.